Phentermine-topiramate was associated with a significant reduction in BMI (mean difference -4.83 kg/m) and weight (mean difference -14.59 kg) in children and adolescents, with a higher proportion of participants achieving a BMI reduction of ≥5%.
The study estimates that expanded access to these medications could avert over 43,000 deaths annually in the US, including more than 12,000 deaths among individuals with type 2 diabetes, highlighting the significant public health benefits of improved access to weight-loss drugs.
Both GLP-1RAs and SGLT-2is resulted in significant weight loss (at least 5%), improved glycemic control, and reduced blood pressure compared to placebo. Semaglutide 2.4mg showed the greatest efficacy in weight loss and glycemic control.
Liraglutide and diet led to weight loss and improved insulin resistance. Liraglutide specifically reduced PAI-1 and the inflammatory marker MCP-1, indicating beneficial cardiovascular effects.
GLP1RAs did not show higher odds of adverse events compared to non-GLP1RA AOMs, and initiation of AOMs 12 months post-surgery was linked to a lower risk of AEs.
Participants experienced significant positive changes, including an average weight loss of 3.82 kg, improved perceived health, reduced sedentary time, and enhanced fitness levels. Effect sizes indicated substantial improvements in health perceptions and physical fitness.
Participants experienced a mean weight loss of 4.13 kg and a reduction in waist circumference by 4.37 cm over 24 months. Improvements were noted in perceived health and attentiveness towards meal size and composition, demonstrating the effectiveness of the intervention across various subgroups.
The exploratory analysis indicated that a decrease in BMI post-surgery was associated with increased connectivity of the nucleus accumbens (NAcc) with medial posterior frontal regions, suggesting a potential relationship between weight loss and brain connectivity changes.
The study found that preoperative MOR availability in the amygdala was significantly associated with long-term postoperative weight loss outcomes, suggesting that higher MOR availability may lead to better weight management after surgery.
80% of participants experienced weight loss during the study, with improvements in gut microbiome composition and health outcomes. The program demonstrated effectiveness in reducing BMI and enhancing metabolic health markers.
Patients in the treatment group reported significant improvements in pain (WOMAC score), activities of daily living (Katz Index of Independence), and mobility (Timed Up and Go test) compared to the control group, with p-values indicating strong statistical significance.
Participants in the experimental group lost an average of 2.62 kg over six weeks, with improvements in physical and mental well-being, while the control group showed negligible weight loss.
Counseling and weight management can help reduce the incidence of complications associated with maternal obesity, leading to healthier pregnancy outcomes and improved maternal health.
Participants in the MBSR group maintained their weight over 6 months, while the control group showed a weight increase, indicating the potential effectiveness of MBSR in weight loss maintenance.
Participants showed improved insulin sensitivity and reduced hedonic value signals related to food liking after weight loss, indicating a positive impact on metabolic health and potential prevention of future metabolic disorders.
The meta-analysis found that orlistat reduced BMI by an average of 0.72 kg/m compared to placebo, with greater reductions observed with longer treatment durations.
The treatment resulted in an average weight loss of 7.73 kg compared to placebo, with significant reductions in waist circumference, blood pressure, blood sugar levels, and lipid levels.
The combination therapy resulted in a mean weight loss of 9.0% after 52 weeks, compared to 5.3% for monotherapy, with a significantly higher odds ratio of 6.7 for achieving at least 15% weight loss in the combination group.
Improved health outcomes and quality of life for minority children through sustained engagement in weight management programs.
Following the interventions, participants showed significant improvements in global cognitive performance, category fluency, and recall scores on cognitive tests. Specifically, there were notable enhancements in immediate and delayed recall, as well as phonemic fluency in the group that received both aerobic and resistance training.
The expected positive outcomes include a reduction in BMI z-scores among children at 24 months of age, improved dietary intake, increased physical activity, better sleep patterns, and overall healthier weight-related measures. The study aims to provide reliable estimates of intervention effects to inform future obesity prevention strategies.
Significant reduction in body weight, fat mass, and lean body mass in the intervention group, with improved insulin sensitivity maintained after the weight loss phase.
Despite the intervention, there were no significant differences in the primary outcomes related to left atrial structure and function between the ILI group and the control group over the 5-year period. Both groups experienced worsening of left atrial parameters, indicating that the intervention did not yield positive outcomes in this context.
Significant increases in WM density were observed 24 months post-surgery, particularly in the cerebellum, brainstem, and corpus callosum. Greater baseline OM adipocyte diameter was linked to more substantial increases in WM density, indicating that individuals with higher visceral fat may experience more pronounced benefits from the surgery.
Postmenopausal women with metabolically healthy overweight/obesity and metabolically unhealthy normal weight had a higher risk of cardiovascular disease than those with metabolically healthy normal weight.
Higher levels of Lac-Phe after acute exercise were linked to a greater reduction in abdominal subcutaneous and visceral adipose tissue, indicating effective fat loss during the intervention.
The study found that PLA levels increased significantly after exercise, correlating with improved insulin sensitivity and reduced subcutaneous adipose tissue volume, indicating a beneficial metabolic response to exercise.
Significant improvements in quality of life, functional strength, and functional capacity were observed in patients using mHealth compared to those without it.
The study found no significant associations between dietary fiber intake and inflammatory markers or hypothalamic microstructure, suggesting that other factors like sex and body composition are more influential.
Bariatric surgery significantly lowers the odds of Major Adverse Cardiovascular Events (MACE) in obese patients with cardiovascular diseases, with an odds ratio of 0.49 compared to those who did not undergo surgery.
Participants exhibited decreased brain activation in response to high-caloric food stimuli, indicating altered food decision-making processes, alongside significant shifts in gut microbiota towards increased SCFA production.
Smaller food portion sizes substantially decrease daily energy intake and are associated with less weight gain over time compared to larger portions.
Increased serum levels of IL-10, improved physical fitness, and potential reduction in obesity-related health risks in children and adolescents.
Understanding the relationship between ACEs and health behaviors can inform interventions to reduce early sexual initiation and obesity among adolescent girls.
Faster rehabilitation weight gain (>12.9 g/kg/day) was associated with higher adult BMI, waist circumference, fat mass, and lean mass, indicating improved body composition in the short term.
Improved accuracy in maternal weight perception may lead to healthier feeding practices, potentially reducing the risk of childhood obesity and associated health issues.
Increased awareness and knowledge about dietary choices among adolescents, with a significant association between sugary food consumption and overweight prevalence.
Patients receiving HFNO showed a higher delta EELI at 1 hour post-surgery, suggesting improved respiratory mechanics compared to conventional oxygen therapy, although the difference was not statistically significant.
Improved newborn outcomes, including reduced risks of low birthweight, SGA, stunting at birth, and macrosomia, through optimal gestational weight gain interventions.
ART-conceived offspring were found to be slightly shorter, lighter, and thinner compared to NC offspring, but these differences were small and reduced with age.
Higher levels of circulating apoM and adiponectin were associated with improved insulin sensitivity and lower HOMA-IR scores. Sleeve gastrectomy led to significant improvements in insulin sensitivity, particularly linked to changes in apoM levels.
Significant weight loss was achieved (-12.4% for overweight patients and -9.14% for non-overweight patients), with improvements in inflammatory markers, blood pressure, glucose metabolism, and liver enzyme levels. COVID and Influenza were negative in over 96% of patients at 14 days.
The study found that among overweight female patients, infliximab had higher odds of achieving remission compared to adalimumab, while obese female patients had lower odds of remission with infliximab. Abatacept showed similar odds of remission compared to adalimumab across all BMI cohorts, contrary to previous hypotheses.
The study confirmed high prevalence rates of obesity-related diseases and established a strong correlation between BMI, waist circumference, and the risk of diabetes, hypertension, and NAFLD.